Waleed Barakat

Professor
waleed.barakat@ejust.edu.eg

Personal Info

Pharmacology & Toxicology

Contact / Personal details:

-       Name: Waleed Mohamed Adel Barakat

-       Birthdate: 25/12/1974

-       Nationality: Egyptian

-       Religion: Muslim

-       Marital status: Married - 3 children

-       Address: Department of Pharmacology & Toxicology - Faculty of Pharmacy - Zagazig University - Egypt.

Education:

-       2009: PhD in Pharmaceutical Sciences (Pharmacology & Toxicology) - Faculty of Pharmacy – Heidelberg University – Germany.

-       2002: Master of Pharmaceutical Sciences (Pharmacology & Toxicology) - Faculty of Pharmacy, Zagazig University, Egypt.

-       1997: Bachelor of Pharmaceutical Sciences - Faculty of Pharmacy, Zagazig University, Egypt.

 

Employment history:

-       2021 - present: Professor at the department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

-       2021 - 2023: Vice Dean for Education & Student Affairs, Faculty of Pharmacy, Zagazig University, Egypt.

-       2015 - 2021: Assistant professor at the department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

-       2014 - 2019: Associate professor at the department of Pharmacology & Toxicology, Faculty of Pharmacy, Tabuk University, Saudi Arabia.

-       2009 - 2014: Lecturer at the department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

-       2005 - 2009: Doctoral student at Heidelberg University, Germany.

-       2002 - 2005: Assistant Lecturer at the department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

-       1998 - 2002: Demonstrator at the department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.

Membership in specialized scientific societies      

1- Member in the Society for Neuroscience (SFN - Regular Category II Membership)

2- Member in Egyptian Society of Diabetic Foot (ESDF)

3- ORCID ID: 0000-0003-2056-3559

 

Participation in activities of scientific journals

1- Reviewer in Journal of Stroke and Cerebrovascular Diseases

2- Reviewer in Journal of Ethnopharmacology

3- Reviewer in Zagazig Journal of Pharmaceutical Sciences

4- Associate editor in chief in Zagazig Journal of Pharmaceutical Sciences (2019 – 2021)

5- Reviewer in OMICS publishing group

6- Reviewer in Bulletin of the National Research Centre

7- Reviewer in Naunyn-Schmiedeberg's Archives of Pharmacology

8- Reviewer in Neurological Research

 

Participation in evaluation of scientific output of Peers:

-     Membership (Evaluator) in Faculty Promotion Committee for evaluation of scientific output for the position of professors and assistant professors (Supreme Council of Universities) - Pharmacology & Clinical Pharmacy (2022-2025).

  • Membership (Evaluator) in the Promotion Committee for evaluation of scientific output for the position of professors and assistant professors (Egyptian Drug Authority). 
  •     Membership (Evaluator) in the Committee for selecting the best PhD Thesis at Kafr Elsheikh University.

Membership in specialized scientific societies      

1- Member in the Society for Neuroscience (SFN - Regular Category II Membership)

2- Member in Egyptian Society of Diabetic Foot (ESDF)

3- ORCID ID: 0000-0003-2056-3559

 

Participation in activities of scientific journals

1- Reviewer in Journal of Stroke and Cerebrovascular Diseases

2- Reviewer in Journal of Ethnopharmacology

3- Reviewer in Zagazig Journal of Pharmaceutical Sciences

4- Associate editor in chief in Zagazig Journal of Pharmaceutical Sciences (2019 – 2021)

5- Reviewer in OMICS publishing group

6- Reviewer in Bulletin of the National Research Centre

7- Reviewer in Naunyn-Schmiedeberg's Archives of Pharmacology

8- Reviewer in Neurological Research

 

Participation in evaluation of scientific output of Peers:

-     Membership (Evaluator) in Faculty Promotion Committee for evaluation of scientific output for the position of professors and assistant professors (Supreme Council of Universities) - Pharmacology & Clinical Pharmacy (2022-2025).

-     Membership (Evaluator) in the Promotion Committee for evaluation of scientific output for the position of professors and assistant professors (Egyptian Drug Authority).

-     Membership (Evaluator) in the Committee for selecting the best PhD Thesis at Kafr Elsheikh University.

Stroke

Diabetic complications

Cell culture



Impacted Journal

1- A Harb, MH Elbatreek, A Elshahat, N El-Akabawy, W Barakat, NM Elkomy. Repurposing alagebrium for diabetic foot ulcer healing: Impact on AGEs/NFκB/NOX1 signaling. European Journal of Pharmacology, 959 (2023) 176083.

2- SS Abdelhady, AR EL-Desouky, AMF Kassab, W Barakat and SH Zoalfakar. Optimization of electrospun chitosan/polyethylene oxide hybrid nanofibril composite via response surface methodology. Journal of Thermoplastic Composite Materials, 2023, Vol. 0(0) 1–25.

3- RH Abdelghany, N Hassan, W Barakat. Targeting AGEs pathway in delayed diabetic wound healing. African Journal of Biological Sciences, 2021: 3 (1), 110-119.

4- W Barakat, H Anwar, M Mahmoud. Sildenafil and Vinpocetine Promote Wound Healing in Diabetic Rats. Journal of Advanced Pharmacy Research, 2021: 5 (1), 211-221.

5- A Yosry, M Abd-Elaal, W Barakat. Modulation of advanced glycation endproducts (AGEs) signaling in experimentally induced stroke in mice. Zagazig Journal of Pharmaceutical Sciences, 2020: 29 (2), 1-10.

6- W Barakat, R Abdelghany, M Nabil, M Abd-Elaal. Nalbuphine ameliorates morphine/tramadol-induced dependence and tolerance to analgesia through locus coereulus (LC) norepinephrine. Zagazig Journal of Pharmaceutical Sciences, 2020: 29 (1), 21-29.

7- R Gamal, W Barakat, NS Helal, E El-ahwany, RH Abdelghany. Itraconazole ameliorates diethylnitrosamine-induced hepatocellular carcinoma in mice. World Journal of Pharmaceutical Sciences, 2019: 7-10.

8- Saleh A, ElFayoumi HM, Youns M, Barakat W. Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions. Naunyn Schmiedebergs Arch Pharmacol. 2019: 392 (2): 165-175.

9- W Barakat, A Fahmy, M Askar, S El-Kannishy. Effectiveness of arginase inhibitors against experimentally induced stroke. Naunyn-Schmiedeberg's archives of pharmacology, 2018: 391 (6), 603-612

10- H Anwer, W Barakat, MF Mahmoud. Effect of vardenafil on diabetic foot ulcer (DFU) in rats. Zagazig Journal of Pharmaceutical Sciences, 2018: 27 (1), 73-85.

11- R H Abdel-Ghany, N Hassan, W Barakat. Partially protective effect of telmisartan on slow healing wounds in diabetic rats: possible role of AGEs-RAGE axis. Zagazig Journal of Pharmaceutical Sciences, 2018: 27 (1), 39-56.

12- M Sabaa, HM ELFayoumi, S Elshazly, M Youns, W Barakat. Anticancer activity of salicin and fenofibrate. Naunyn-Schmiedeberg's archives of pharmacology. 2017: 390 (10), 1061-1071.

13- A Yosry, M Abd-Elaal, W Barakat. The possible role of advanced glycation endproducts (AGEs) in experimentally-induced ischemic brain damage. Zagazig Journal of Pharmaceutical Sciences, 2017: 26 (2), 78-86.

14- A Saleh, HM ELFayoumi, and W Barakat. Possible anticancer effects of rutin and orlistat in Ehrlich-ascites carcinoma in mice. Zagazig J. Pharm. Sci. Dec, 2017, Vol. 26, Issue 2, pp, 55-66.

15- SM Elshazly, AAA Mahmoud, W Barakat. Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats. Canadian journal of physiology and pharmacology, 2016: 94 (11), 1170-1177.

16- S El-Kannishy, A Aboelnour, W Barakat, MS Abdel-Maksoud, AA AL Yousef. Endocrinal dysfunction of Hypothalamo Pitutary Gonadal Axis in seminal plasma of Cigarette Smoking Males. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2016: 7 (1): 461 – 468.

17- RH Abdel-Ghany, W Barakat, AA Shahat, WES Abd-Allah, EA Ali. In vitro and in vivo hepatoprotective activity of extracts of aerial parts of Bidens pilosa L (Asteraceae). Tropical Journal of Pharmaceutical Research, 2016: 15 (11), 2371-2381.

18- R Abdel-Ghany, E Mohammed, S Anis, W Barakat. Impact of exposure to fenitrothion on vital organs in rats. Journal of toxicology vol. 2016: 5609734.

19- R Abdel-Ghany, S Anis, A Bihery, W Barakat. Effect of Punica and Silymarin on hepatotoxicity induced by pesticides. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2016: 6 (1), 41-47.

20- R Abdel-Ghany, I Rabia, E El-Ahwany, S Saber, R Gamal, F Nagy, O Mahmoud, RS Hamad, W Barakat. Blockade of PGE2, PGD2 Receptors Confers Protection against Prepatent Schistosomiasis Mansoni in Mice. J. Egypt. Soc. Parasitol. (JESP), 45(3), 2015: 511 -520.

21- R Abdel-Ghany M Nabil, M Abdel-Aal, W Barakat. Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity. European Journal of Pharmacology, 2015: 758 11–15.

22- W Barakat, Shimaa M. Elshazly, and Amr A. A. Mahmoud. Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice. Advances in Pharmacological Sciences, 2015: Article ID 132873, 8 pages.

23- MN Zakaria, HM. El-Bassossy and W Barakat. Targeting AGEs Signaling Ameliorates Central Nervous System Diabetic Complications in Rats. Advances in Pharmacological Sciences, 2015: Article ID 346259, 9 pages.

24- W Barakat, A Fahmy and M Askar. Neuroprotective Effect of L-Norvaline against Ischemic Brain Damage in Rats. Clinical Research and Development, 2015: 2 (3): 117.

25- AM Lotfy, W Barakat, RH Abd Elghany.  Neuroprotective effects of albumin, pioglitazone and insulin against ischemic brain damage in mice.  Zagazig J. Pharm. Sci. June., 2015, Vol. 24, Issue. 1, pp 35-46.

26- W Barakat, S El-kannishy, SM Elshazly, AAA Mahmoud and NA Ahmed.  Ameliorative Effect of Glycyrrhizic Acid against Doxorubicin-Induced Cardiotoxicity in Rats. Clinical Research and Development, 2015: 2 (2): 116.

27- S Saleh, N El-Maraghy, E Reda, W Barakat. Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin: Role of Adiponectin and TNF-α. Anais da Academia Brasileira de Ciências, 2014: 86 (4).

28- R Abdel-Ghany, E Mohammed, S Anis  and W Barakat. Dietary supplementation with Punica and Physalis attenuates the deleterious effects of Fenitrothion in rats. Zagazig J. Pharm. Sci., 2014: Vol. 23, Issue. 2.

29- W Barakat, R Hassan, M Askar, and A Fahmy. Role of aldose reductase and arginase inhibitors in diabetic vascular and behavioral complications. Zagazig J. Pharm. Sci. June., 2014: Vol. 23, Issue. 1.

30- Elshazly S M, El-Moselhy M A, Barakat W. Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity. European Journal of Pharmacology,  2014: 726: 116–123.

31- Barakat W, Safwet N, El-Maraghy N N, Zakaria M N M. Candesartan and glycyrrhizin ameliorate ischemic brain damage through downregulation of the TLR signaling cascade. European Journal of Pharmacology, 2014: 724: 43–50.

32- Ibrahim S M,. Abo-Kul M, Soltan M K, Barakat W and Helal A S. Synthesis and biological screening of new derivatives of 2,3-dihydro quinazolin-4(1H)-one and benzotriazepin- 5(2H)-one for central nervous system activity. International Journal of Pharmaceutical Chemistry, 2014: 04 (01).

33- Waleed Barakat, Mohamed Nabil Mahrous, and Mohamed Naguib Zakaria. Docosahexanoic acid (DHA) reduces brain damage induced by reversible middle cerebral artery occlusion (MCAO) in mice. Zagazig J. Pharm. Sci. Dec., 2013: Vol. 22, Issue. 2

34- Samir A, El-Megrab N, Fattah H A, Barakat W. Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Technique. Asian J. Research Chem., 2012: 5(4).

35- Fattah H A, Hammad M A, El-Megrab N, Barakat W, Samir A. Modulation of Clonazepam Solubility using Solid Dispersion Technique Improves its Solubility and Bioavailability. Asian J. Research Chem., 2012: 5(4).

36- Abdallah M H, Sammour O A, El-ghamry H A, El-nahas H M and Barakat W. Development and Characterization of Controlled Release Ketoprofen Microspheres. Journal of Applied Pharmaceutical Science, 2012: 02 (03): 60-67.

37- Mahmoud MF, El Shazly SM, Barakat W. Inhibition of TNF-α protects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway. Naunyn-Schmiedeberg's Arch Pharmacol, 2012: 385:465–471.

38- Ibrahim T S, Rashad A A, Abdel-Samii Z K, El-Feky S A, Abdel-Hamid M K, Barakat W. Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-Benzotriazinone Derivatives. Medicinal Chemistry Research, Published online, 2012: 28.

39- Bargiotas P, Krenz A, Hormuzdi S, Ridder D A, Herb A, Barakat W, Penuela S, von Engelhardt J, Monyer H, Schwaninger M. Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci USA. (PNAS), 2011 Dec 20; 108(51): 20772-7.

40- Barakat W, Herrmann O, Baumann B, Schwaninger M. NF-κB induces PgE2 synthesizing enzymes in neurons. Naunyn Schmiedebergs Arch Pharmacol, 2009: 380(2): 153-160.

41- Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, Bendszus M, Rossetti G, Nawroth PP, Bierhaus A, Schwaninger M. The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci, 2008: 28:12023-12031.


International Conference

1- DUPHAT 2019: Dubai International Pharmaceutical & Technologies Conference & Exhibition (26 - 28 February): Poster: Coronary heart disease in Tabuk: Prevalence, knowledge about a major fatal disease.

2- DUPHAT 2018: Dubai International Pharmaceutical & Technologies Conference & Exhibition (27 February – 1 March): 6th  Best thematic Pharmacy Poster: Stroke in Tabuk, KSA: Awareness and prevalence of risk factors.

3- The 49th Jahrestagung of the Deutsche Geselleschaft fuer Experimentelle, Klinische Pharmakologie & Toxikologie e.V. March 2008, Mainz, Germany.


Funded Research Grants

1- The Possible neuroprotective effect of incretin based therapy in mice with ischemic stroke - Science and Technology Development Fund (STDF) (02/2025 – 02/2027) - Thesis supervisor of the Principle Investigator.

2- Repurposing Drugs targeting TLR4 and NRF2 signaling for ischemic stroke in mice - Science and Technology Development Fund (STDF) (02/2025 – 02/2027) - Thesis supervisor of the Principle Investigator.

3- Artificial intelligence (AI)-guided identification of effective anti-stroke molecule(s): from databases to experimental models - STDF: U.S. - Egypt Joint Board on Scientific and Technological Cooperation (submitted December 2023: Evaluation in progress) - Principle Investigator (PI).

4- Effectiveness of natural compounds against experimentally-induced stroke - Tabuk University (S-1438-096) (2017 – 2018) - Principle Investigator (PI).

5- Possible protective effect of glycyrrhizin against doxorubicin-induced cardiotoxicity in rats - Tabuk University (S-1436-0151) (2015 – 2016) - Principle Investigator (PI).

6- Role of Physalis Peruviana and Punica Granatum in treatment of pesticides induced-hepatotoxicity and its neuronal complications in rats. Clinical prevalence of hepatic encephalopathy - Academy of scientific research and technology (6/2013-6/2015) - Thesis supervisor of the Principle Investigator.

7- Novel Therapeutic Strategies for Treatment of Diabetic Vascular Complications - Science and Technology Development Fund (STDF) (10/2009 – 07/2013) - Second Assistant Investigator (AI2).

8- Targeting Major Health Problems in Egypt: Novel Target(s) For the Management of Diabetic Complications - Zagazig University (6/2009 - 6/2011) - Principle Investigator (PI).



National Conference

1- First Scientific conference at the Faculty of Pharmacy, Zagazig University.  March 2011

2- Third Scientific conference at the Faculty of Pharmacy, Zagazig University. March 2013

3- Third student conference at the Faculty of Pharmacy, Zagazig University. March 2013

4- The 4th Diabetic Foot Conference of the Egyptian Society of Diabetic Foot (ESDF). October 2012.

5- The 32nd Conference of Pharmaceutical Sciences. December 2011, Cairo, Egypt. 

Courses Teaching

Teaching activities – Faculty of Pharmacy – Zagazig University - Egypt:

-     Participating in teaching Courses at the department of Pharmacology & Toxicology –:

Undergraduate (General – Clinical programs)

o  2009-2014: (35 courses)

o  2019-2025: (53 courses)

Postgraduate (Master preliminary - Master special - PhD Special - Biochemistry Diploma - Toxicology & Forensic Chemical Analysis Diploma):

o  2009-2014: (12 courses)

o  2019-now: (9 courses)

Teaching activities – Faculty of Pharmacy – Misr International University (MIU):

-     Participating in teaching undergraduate courses at the Department of Pharmacology & Toxicology (2012-2013: 5 courses)

Teaching activities – Faculty of Pharmacy – Tabuk University - KSA:

-     Participation in teaching undergraduate courses (2014-2019: 20 courses)

Non Regular Seminars

Examples of honor certificates and conferences participated in.

1- 3-2018: Stroke: Etiology & Prevention

2- 2-2017: Patient Counseling Pharmacy Exhibition

3- 3-2014: Third Student Conference of Faculty of Pharmacy

4- 2014: Certificate for contributing in the activities leading to accreditation of the faculty

5- 9-2013: Scientific research ethics

6- 3-2013: Third Scientific Conference of Faculty of Pharmacy

7- 3-2013: Presentation in the 3rd Scientific Conference of Faculty of Pharmacy

8- 3-2013: Best presentation in the 3rd Scientific Conference of Faculty of Pharmacy

9- 2-2013: Real Time PCR Technology

10- 1-2013: Ethical Rules of Scientific Research & Clinical, Microbiological & Biological Waste Disposal

11- 10-2012: The 4th Diabetic Foot Conference of the Egyptian Society of Diabetic Foot (ESDF)

12- 2012: Certificate for international scientific publication 2012

13- 2012: Certificate for presentation on First Aid

14- 12-2011: Egyptian Pharmaceutical Society 32nd Conference

15- 3-2010: The ESPET 51st Conference -(The Egyptian Society of Pharmacology & Experimental Therapeutics)

16- 2010: Certificate for research & international scientific

17- 2010: Certificate for international scientific publication award

18- 2010: Certificate for scientific research project

19- 2010: Scientific Conference of Faculty of Pharmacy

20- 2009: Certificate from the Library team