Mahmoud Soliman

Professor of Pharmaceutics and Industrial Pharmacy
mahmoud.soliman@ejust.edu.eg

Personal Info

B8 F2 18

Pharmaceutics and Industrial Pharmacy

Prof. Mahmoud Eid Soliman graduated from the Faculty of Pharmacy, Alexandria University (1998). In 2005, he received his MSc degree from Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University. Finished PhD thesis titled “Targeted polyplexes of sequence-varied reducible polycations for gene delivery” from Division of Drug Delivery and Tissue Engineering, School of Pharmacy, Nottingham University, Nottingham, UK (2010). In 2021 awarded Professorship, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. 2021 - present awarded Professorship, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, E-JUST, New Borg ElArab, Alexandria, Egypt. 

 

Research interests include synthesis of polymers, developing new methodologies for assembling drug delivery systems to target cancer and brain and the preparation and pharmacokinetics of drug delivery systems smartly delivering antidiabetic and antiepileptic drugs. He has published more than 40 international publications (most of which are in the fields of drug and gene delivery as well as biophysical analysis), and a 2 book chapters published by Elsevier. On the industrial experience level, participated in a number of projects as a scientific consultant and expert in the fields of drug delivery system characterizations as well as in the field of prescription drug regulation, cost, and access.

In the field of Pharmaceutics, Drug Delivery, Tissue Engineering and Biophysical Analysis

Proficient in the use of various microscopes, sample preparation, dyeing and imaging using SEM, TEM Fluorescence Microscope and AFM.

Experienced in synthesis and analysis of polymers using NMR, FTIR, GPC and MALLS techniques

Experienced in preparing nanoparticles, microparticles and their composites then characterizing them using Rheometry, DLS and Zeta potential measurement, XPS, QCM and EDX techniques.

Experienced in development of novel pH responsive vectors for gene delivery (Artificial Viruses) which include modulation of synthetic vector-nucleic acid binding, transport of nucleic acid viral-mimetic carriers through cell membranes and triggered release of nucleic acids within the cytoplasm and/or nucleus.

Experienced in preparation of liposomes and its transformation into supported lipid bilayers and studying the interaction of polypeptides with the formed layers.

 


Awards

2014: Post Doctor mission at Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham awarded by Cultural Affairs and Mission Sector of the Egyptian Ministry Of Higher Education.
2013: Post Doctor mission at Division of Drug Delivery and Tissue Engineering, School of Pharmacy, University of Nottingham awarded by British Academy of Medical Sciences.
2012: Award of Misr El Kheir Foundation for his published research in the field of biological sciences.

2011-2020: Ain Shams University award for international publication.

 


Impacted Journal

1. Nasanit, R., P. Iqbal, M. Soliman, N. Spencer, S. Allen, M.C. Davies, S.S. Briggs, L.W. Seymour, J.A. Preece, and C. Alexander, Combination dual responsive polypeptide vectors for enhanced gene delivery. Molecular BioSystems, 2008: 4(7): p. 741-745.

2. Stevenson, M., V. Ramos-Perez, S. Singh, M. Soliman, J.A. Preece, S.S. Briggs, M.L. Read, and L.W. Seymour, Delivery of siRNA mediated by histidine-containing reducible polycations. Journal of Controlled Release, 2008: 130(1): p. 46-56.

3. Soliman, M., S. Allen, M.C. Davies, and C. Alexander, Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics. Chemical Communications, 2010: 46(30) p. 5421-5433.

4. Soliman, M., R. Nasanit, S. Allen, M.C. Davies, S.S. Briggs, L.W. Seymour, J.A. Preece, and C. Alexander, Interaction of reducible polypeptide gene delivery vectors with supported lipid bilayers: pore formation and structure–function relationships. Soft Matter, 2010: 6(11) p. 2517-2524.

5. Saeed, A., J. Magnusson, E. Moradi, M. Soliman, W. Wang, S. Stolnik, S. Howdle, and C. Alexander, Modular construction of multifunctional bioresponsive cell targeted nanoparticles for gene delivery. Bioconjugate Chemistry, 2011: 16;22(2) p.156-68.

6. Soliman, M., R. Nasanit, S.R. Abulateefeh, S. Allen, M.C. Davies, S.S. Briggs, L.W. Seymour, J.A. Preece, A.M. Grabowska, S.A. Watson, and C. Alexander, Multicomponent synthetic polymers with viral-mimetic chemistry for nucleic acid delivery. Molecular Pharmaceutics, 2012: 9(1) p.1-13.

7. Casettari, L., D. Vllasaliu, J.K. Lam, M. Soliman, and L.Illum. Biomedical applications of amino acid-modified chitosans: a review. Biomaterials, 2012: 33(30) p.7565-83.

8. Elazreg, R., M. Soliman, S. Mansour and A. El Shamy, preparation and evaluation of mucoadhesive gellan gum in-situ gels for the ocular delivery of carbonic anhydrase inhibitor nanovesicles. International Journal of Pharmaceutical Science Research, 2014: 6(9) p.3761-74.  

9. Shalaby, K., M. Soliman, L. Casettari, G. Bonacucina, M. Cespi, G. Palmieri, O. Sammour, A. El Shamy. Determination of factors controlling the particle size and entrapment efficiency of noscapine in PEG/PLA nanoparticles using artificial neural networks. International Journal Nanomedicine,  2014: 9 p.4953-64

10. Martarelli, D., L Casettari , K. Shalaby, M. Soliman, M. Cespi, G. Bonacucina, L. Fagioli, D. Perinelli, J. Lam, G. Palmieri. Optimization of melatonin dissolution from extended release matrices using artificial neural networking. Current Drug Delivery,  2016: 13(4) p. 565-73.

11. El-Zaafarany, G., M. Soliman, S. Mansour, G. Awad. Identifying lipidic emulsomes for improved oxcarbazepine brain targeting: in-vitro and rat in-vivo studies. International Journal of Pharmaceutics, 2016: 503 p.127–140.

12. Soliman, M., E. Elmowafy, A. Almogerbi, S. Holayel, A. El Shamy Dual buoyant/mucoadhesive macroporous polypropylene microparticles for gastric delivery of repaglinide. International Journal of Drug Delivery, 2015: 7

13. Shalaby, K., M. Soliman, G. Bonacucina, M. Cespi, G. Palmieri, O. Sammour, A. El Shamy. , L. Illum L. Casettari, Nanoparticles based on linear and star-shaped poly(ethylene glycol)- poly(ε-caprolactone) copolymers for the delivery of antitubulin drug. Pharmaceutical Research, 2016: 13 p.1-15

14. Perinelli, D.R., M. Cespi, S. Pucciarelli, S. Vincenzetti, L. Casettari, J.K.W. Lam, S. Logrippo, E. Canala, M. Soliman, G. Bonacucina, G.F. Palmieri. Microemulsions for protein delivery: loading optimization and stability. Current Pharmaceutical Biotechnology, 2017: 7.

15. Eilleia,  S.Y., M.E. Soliman, S. Niedermayer, A. Schmidt, S. Mansour, A.S. Geneidi. Examining insulin adsorption onto mesoporous silica microparticles for oral delivery. Current Drug Delivery, 2018: 15(4) p.541-553.

16. Eilleia, S.Y., M.E. Soliman, S. Mansour, A.S. Geneidi. Novel technique of insulin loading into porous carriers for oral delivery, Asian Journal of Pharmaceutical Sciences,

2018: 13 (4) p.297-309

17. Soliman, M. E., E.  Elmowafy, L. Casettari, C. Alexander. Star-shaped poly(oligoethylene glycol) copolymer-based gels: Thermo-responsive behaviour and bioapplicability for risedronate intranasal delivery. International Journal of Pharmaceutics, 2018: 30;543(1-2):224-233.

18. Alazzo, A. , T. Lovato,  H. Collins, V. Taresco, S. Stolnik, M. Soliman,  K. Spriggs, C. Alexander. Structural variations in hyperbranched polymers prepared via thermal polycondensation of lysine and histidine and their effects on DNA delivery. Journal of Interdisciplinary Nanomedicine,. 2018: 3(2) p.38-54.

19. El-Zaafarany, G., M. Soliman, S. Mansour, M. Cespi, G. Palmieri, L. Illum, L. Casettari, G. A. Awad. Tailored thermosensitive PLGA-PEG-PLGA/emulsomes composite for enhanced oxcarbazepine brain delivery via the nasal route. Pharmaceutics, 2018: 5;10 (4) p.217

20. Elmowafy, E., M. Tiboni, and M. Soliman. Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles. Journal of Pharmaceutical Investigation, 2019: p.1-34

21. Burhan, A., S. Abdel-Hamid, M. Soliman, OA Sammour. Optimization of the Microencapsulation of Lavender Oil by Spray Drying Journal of microencapsulation, 2019: p.1-42

22. Elmowafy, E, H. Gad, F. Biondo, L. Casettari, M. Soliman. Exploring optimized methoxy poly (ethylene glycol)-block-poly (ε-caprolactone) crystalline cored micelles in anti-glaucoma pharmacotherapy. International Journal of Pharmaceutics, 2019: 566, , p. 573-584

23. Elmowafy, E., M. Soliman. Losartan-chitosan/dextran sulfate microplex as a carrier to lung therapeutics: Dry powder inhalation, aerodynamic profile and pulmonary tolerability. International journal of biological macromolecules, 2019: 136, p. 220-229

24. Shamarekh, K., H. Gad, M. Soliman, O. Sammour. Towards the production of monodisperse gelatin nanoparticles by modified one step desolvation technique. Journal of Pharmaceutical Investigation, 2019: p. 1–12

25.  Abou-ElNour, M., R. Ishak, M. Tiboni, G. Bonacucina, M. Cespi, L. Casettari, M. Soliman, A. Geneidi, Triamcinolone acetonide-loaded PLA/PEG-PDL microparticles for effective intra-articular delivery: Synthesis, optimization, in vitro and in vivo evaluation. Journal of Controlled Release, 2019: 309, p. 125-144

26. Elmowafy, E., G. Bonacucina, M. Cespi, M. Soliman. In-situ composite ion-triggered gellan gum gel incorporating amino methacrylate copolymer microparticles: A therapeutic modality for buccal applicability. Pharmaceutical Development and Technology, 2019: 24, p.1258-1271

27. Molinaro, R., A. Gagliardi, A. Mancuso, D. Cosco, M. Soliman, L. Casettari, D. Paolino. Development and in vivo evaluation of multidrug ultradeformable vesicles for the treatment of skin inflammation. Pharmaceutics. 2019:11, p.644

28. Elmowafy, E., M. O. El-Derany, F. Biondo, M. Tiboni, L. Casettari, and M. Soliman. Quercetin loaded monolaurate sugar esters-based niosomes: sustained release and mutual antioxidant-hepatoprotective interplay. Pharmaceutics. 2020:12, p.43

29. Tiboni M, Elmowafy E, El-Derany MO, Benedetti S, Campana R, Verboni M, Potenza L, Palma F, Citterio B, Sisti M, Duranti A. Lucarini S, Soliman M, Casettari L. A combination of sugar esters and chitosan to promote in vivo wound care. International Journal of Pharmaceutics. 2022 Mar 25;616:121508.

30. Zaher S, Soliman ME, Elsabahy M, Hathout RM. Sesamol loaded albumin nanoparticles: a boosted protective property in animal models of oxidative stress. Pharmaceuticals. 2022 Jun 10;15(6):733.

31. Elmowafy E, Pavoni L, Perinelli DR, Tiboni M, Casettari L, Cespi M, El-khouly A, Soliman ME, Bonacucina G. Hyperlipidemia control using the innovative association of lupin proteins and chitosan and α-cyclodextrin dietary fibers: food supplement formulation, molecular docking study, and in vivo evaluation. European Food Research and Technology. 2022 Dec;248(12):2977-93.

32. Elmowafy E, O El-Derany M, Casettari L, Soliman ME, El-Gogary RI. Gamma oryzanol loaded into micelle-core/chitosan-shell: from translational nephroprotective potential to emphasis on sirtuin-1 associated machineries. International Journal of Pharmaceutics. 2023 Jan;631:122482.

33. Omnia A. Al-wdan, Omnya A. Sharallah, Nada A. Abdelwahab, Alshimaa O. Mohammed, Elmowafy E., Soliman M. Insights into microfabrication and implementation of microfluidics in pharmaceutical drug delivery and analysis, OpenNano, 2023, 100156.

34. Elmowafy E, Soliman ME. Polysaccharide-based platforms for nasal delivery: design, features, and perspectives. Journal of Pharmaceutical Investigation. 2023 Sep;53(5):571-99.

35. Zaher S, Soliman ME, Elsabahy M, Hathout RM. Protein nanoparticles as natural drugs carriers for cancer therapy. Advances in Traditional Medicine. 2023 Dec;23(4):1035-64.

36. Sarhan FA, ElGogary R, Yassin M, Soliman ME. Penetration enhancer containing vesicles for dermal and transdermal drug delivery. A review. Archives of Pharmaceutical Sciences Ain Shams University. 2023 Dec 10.

37. Mahmoud MH, El-Gogary RI, Soliman ME, Kamel AO. Novel green-based polyglycerol polymeric nanoparticles loaded with ferulic acid: A promising approach for hepatoprotection. International Journal of Biological Macromolecules. 2024 Apr 1;264:130698.

38. Elmowafy E, Hammad S, Soliman ME. Exploiting Ascorbyl Palmitate Assisted-Chondroitin Sulfate/Chitosan Nanoparticles for Intra-articular Delivery of Lipoic Acid. Carbohydrate Polymer Technologies and Applications. 2024 Jun 1;7:100459.

39. Elgiushy HR, Soliman ME, El-Khouly ME, Abouzid K, F Hammad S. Discovery of Pyrazolo [1, 5-A] Pyrimidines: Synthesis, in Silico Insights, and Anticancer Activity Via Novel Cdk2/Tubulin Dual Inhibition Approach. Silico Insights, and Anticancer Activity Via Novel Cdk2/Tubulin Dual Inhibition Approach.


International Conference

1. Soliman, M., Pack, J., Nasnit, R., Iqbal, P., Allen, S., Davies, M., Preece, J., Alexander, C.

Biophysical Investigations into Synthetic Histidine Rich Polypeptide -DNA Complexes. RSC /SCI Macro Group Young Researchers Meetings, April 11-12, 2007, Nottingham, UK.

2. Soliman, M., Pack, J.L., Nasnit, R., Iqbal, P., Allen, S., Davies, M., Preece, J., Alexander, C. AFM Studies of DNA Unpackaging From Polyplexes of Sequence-Varied Reducible Polycations. 36th Annual Meeting & Exposition of the Controlled Release Society, July 18- 22, 2009, Copenhagen, Denmark.

3. Soliman, M., Pack, J.L., Nasnit, R., Iqbal, P., Allen, S., Davies, M., Preece, J., Alexander, C. Novel Acid Cleavable PEGylated Gene Delivery Systems Based On Reducible Polypeptides. RSC /SCI Macro Group Young Researchers Meetings, April 29-30, 2010, Nottingham, UK.

4. Soliman, M., Pack, J.L., Nasnit, R., Iqbal, P., Allen, S., Davies, M., Preece, J., Alexander, C. Depolymerization of Sequence Varied Reducible Polypeptides as a Mechanism of DNA Unpackaging from Their Polyplexes. Humboldt Kolleg: Pharmaceutical and Biotechnological Therapies. Alexander von Humboldt Foundation, Germany and the German University in Cairo; September 28 - October 1, 2012, Cairo, Egypt.

5. Casettari, L., Soliman, M., Scalera, F., Spagnolo, M., Cespi, M., Bonacucina, G., Gervaso, F., Palmieri, G., Sannino, A. Biodegradable Scaffolds of Chitosan and PEGylated Polyesters. 11th International Conference EUCHIS, May 5-8, 2013, Porto, Portugal.

6. Shalaby, K., Soliman, M., Casettari, L., Sammour, O., El-Shamy, A. Biodegradable Polymeric Nanoparticles for Selective Release of Noscapine in Breast Cancer Cells.

PharmSci UK Conference, September 2-4, 2013, Edinburgh, UK.

7. Casettari, L., Shalaby, K., Soliman, M., Sammour, O., El-Shamy, A., Bonacucina, G., Cespi, M., Palmieri, G. Artificial Neural Networks Applied To Biodegradable Nanoparticles For Noscapine Delivery. Nanomedicine Conference, September 17-19, 2014, Viterbo, Italy.

8. Eilleia, S., Soliman, M., Holayel, S., Geneidy, A., Niedermayer, Schmidt, S., Bein, T. Peptide Post Encapsulation onto Porous Polymeric and Inorganic Microparticles. 42nd Annual Meeting & Exposition of the Controlled Release Society, July 26-29, 2015, Edinburgh, UK.

9. Casettari, L., Soliman, , M., Shalaby, K., Bonacucina, G., Cespi, M., Fagioli, L., Perinelli, D., Palmieri, G. Noscapine Loaded Biodegradable Nanoparticles to Treat Breast Cancer. 10th World meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 4-7, 2016, Glasgow, UK.


Funded Research Grants

Jojoba Oil: research for industrial products, (Member) of Agricultural/ Medicinal and Pharmaceutical track

HAPPYCO Company Project (Member)Valorization of Crawfish waste and rationalizing energy and water uses.

JICA Research Grant – Type B1- 2025 (TB1-25-9) (PI) Development of Jojoba Oil-Based Topical Pharmaceutical Formulations for Wound Healing



National Conference

From monomer to therapeutic nanocarrier: design, Characterization, and anticancer evaluation of poly (alpha-lipoic Acid) nanoparticles. Al-Hussein Mekki,Mahmoud Soliman, Amr Nassrallah. International SConference on Research in Engineering, Technology and Science (ICRETS), Peja/Kosovo, 2025

Preparation and Characterization of Green Curcumin Loaded Polyglycerol Polymeric Nanoparticles: Stability and Molecular Docking. Rania H Ahmed, Mahmoud E Soliman, Sherif F Hammad, Hesham S Soliman, Ahmed Abdelmowgood. International SConference on Medical, Biological and Pharmaceutical Sciences(ICMBPS-25),Alexandria/Egypt, 2025

Courses Teaching

For Undergraduates

·         Physical Pharmacy and Pharmacy Orientation

·         Disperse Systems (Solutions- Suspensions-Emulsions)

·         Semisolids (Ointments – Creams)

·         Suppositories

·         Cosmetics

·         Sterile Products

·         Aerosols

·         Biopharmaceutics and Pharmacokinetics

·         Industrial Pharmacy

 

For Postgraduates

·         Applications of Nanotechnology in Pharmacy

·         Solubility Parameters

·         Supercritical Fluids

·         Tissue Engineering

·         Polymers in Pharmacy